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Fluconazole, 99%

Produktkod. 15454479
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Produktkod. 15454479 Leverantör Thermo Scientific Alfa Aesar Leverantörsnummer J62015.03
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Beskrivning

Fluconazole, CAS # 86386-73-4, is a synthetic triazole with antifungal activity against some species of Candida. It also shows inhibitory activity against cytochrome P-450 enzymes and it is a demethylase. | CAS: 86386-73-4 | C13H12F2N6O | 306.277 g/mol

Fluconazole is used to treat a variety of fungal infections, especially Candida infections of the vagina (yeast infections), mouth, throat and bloodstream. It is also used by the people having weak immune system such as persons with neutropenia due to cancer chemotherapy, transplanted patients and premature infants.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species
  • It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity
  • It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)
  • Mammalian cell demethylation is much less susceptible to fluconazole inhibition

Applications

  • Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.
  • Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene
  • In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays
  • It has also been used as a positive control in antifungal assay of plants
TRUSTED_SUSTAINABILITY

Kemiska identifierare

CAS 86386-73-4
Molekylformel C13H12F2N6O
Molekylvikt (g/mol) 306.277
MDL-nummer MFCD00274549
InChI-nyckel RFHAOTPXVQNOHP-UHFFFAOYSA-N
Synonym fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol
PubChem CID 3365
ChEBI CHEBI:46081
IUPAC-namn 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
LEDER C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O

Specifikationer

Kemiskt namn eller material Fluconazole
Smältpunkt 138°C to 140°C
Färg White
Densitet 1.05
Kvantitet 1 g
Merck Index 14,4122
Löslighetsinformation Soluble indimethylsulfoxide and ethanol.
Formel vikt 306.27
Procent renhet 99%
Fysisk form Crystalline Powder

Säkerhet och hantering

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Produktbeteckning
  • Fluconazole
 Signalord
  • Fara
 Riskkategorier
  • Akut toxicitet Kategorija 4
  • Allvarlig ögonskada/ögonirritation Kategorija 2
  • Reproduktionstoxicitet Kategorija 1B
  • Frätande eller irriterande verkan på hud Kategori 2
  • Specifik organtoxicitet - enstaka exponering Kategorija 2
 Faroangivelser
  • H302-Skadligt vid förtäring.
  • H315-Irriterar huden.
  • H319-Orsakar allvarlig ögonirritation.
  • H360D-Kan skada det ofödda barnet.
  • H371-Kan orsaka organskador.
 Skyddsangivelse
  • P280-Använd skyddshandskar/skyddskläder/ögonskydd/ansiktsskydd.
  • P301+P330+P331-VID FÖRTÄRING: Skölj munnen. Framkalla INTE kräkning.
  • P302+P352-VID HUDKONTAKT: Tvätta med mycket vatten/.
  • P305+P351+P338-VID KONTAKT MED ÖGONEN: Skölj försiktigt med vatten i flera minuter. Ta ur eventuella kontaktlinser om det går lätt. Fortsätt att skölja.
  • P312-Vid obehag, kontakta GIFTINFORMATIONSCENTRALEN/läkare/ .
 Kompletterande information
  • MIXTURE LIST-Contain: Fluconazole

RUO – Research Use Only

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