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Fluconazole, 99%, Thermo Scientific™
Fluconazole, CAS # 86386-73-4, is a synthetic triazole with antifungal activity against some species of Candida. It also shows inhibitory activity against cytochrome P-450 enzymes and it is a demethylase.
Brand: Thermo Scientific Alfa Aesar J62015.03
| Kvantitet | 1g |
|---|
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Beskrivning
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
• Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species
• It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity
• It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)
• Mammalian cell demethylation is much less susceptible to fluconazole inhibition
Applications
• Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.
• Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene
• In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays
• It has also been used as a positive control in antifungal assay of plants
Kemiska identifierare
| 86386-73-4 | |
| 306.277 | |
| RFHAOTPXVQNOHP-UHFFFAOYSA-N | |
| 3365 | |
| 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol |
| C13H12F2N6O | |
| MFCD00274549 | |
| fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol | |
| CHEBI:46081 | |
| C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O |
Specifikationer
| Fluconazole | |
| 1.05 | |
| MFCD00274549 | |
| 14,4122 | |
| Soluble indimethylsulfoxide and ethanol. | |
| C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O | |
| 306.277 | |
| CHEBI:46081 | |
| 99% |
| 86386-73-4 | |
| C13H12F2N6O | |
| 1g | |
| fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol | |
| RFHAOTPXVQNOHP-UHFFFAOYSA-N | |
| 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol | |
| 3365 | |
| 306.27 |
Säkerhet och hantering
Produktbeteckning
Signalord
Riskkategorier
Faroangivelser
Skyddsangivelse
Kompletterande information
- Fluconazole
Signalord
- Fara
Riskkategorier
- Akut toxicitet Kategorija 4
- Allvarlig ögonskada/ögonirritation Kategorija 2
- Reproduktionstoxicitet Kategorija 1B
- Frätande eller irriterande verkan på hud Kategori 2
- Specifik organtoxicitet - enstaka exponering Kategorija 2
Faroangivelser
- H302-Skadligt vid förtäring.
- H315-Irriterar huden.
- H319-Orsakar allvarlig ögonirritation.
- H360D-Kan skada det ofödda barnet.
- H371-Kan orsaka organskador.
Skyddsangivelse
- P280-Använd skyddshandskar/skyddskläder/ögonskydd/ansiktsskydd.
- P301+P330+P331-VID FÖRTÄRING: Skölj munnen. Framkalla INTE kräkning.
- P302+P352-VID HUDKONTAKT: Tvätta med mycket vatten/.
- P305+P351+P338-VID KONTAKT MED ÖGONEN: Skölj försiktigt med vatten i flera minuter. Ta ur eventuella kontaktlinser om det går lätt. Fortsätt att skölja.
- P312-Vid obehag, kontakta GIFTINFORMATIONSCENTRALEN/läkare/ .
Kompletterande information
- MIXTURE LIST-Innehåller: Fluconazole
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