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FOXP3 Rat anti-Chimpanzee, Cynomolgus Monkey, Human, Non-human primate, Rhesus Monkey, PE, Clone: PCH101, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-4776-41

Additional Details : Weight : 0.23750kg

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Product Code. 15506986

  • 1486.00 SEK / 25 tests


EU Stock 3
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Description

Description

Applications Tested: This PCH101 antibody has been pre-titrated and tested by intracellular flow cytometric analysis of human peripheral blood leukocytes using the Anti-Human Foxp3 PE Staining Set (cat. 72-5776) and protocol. Refer to Best Protocols- (refer to Protocol B: One-step protocol for intracellular (nuclear) proteins). This can be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10e5 to 10e8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
Specifications

Specifications

Foxp3
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
Q9BZS1
AIID, DIETER, Forkhead box P3, foxp3, IPEX, JM2, PIDX, SCURFIN, XPID
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Chimpanzee, Cynomolgus Monkey, Human, Non-human primate, Rhesus Monkey
Flow Cytometry
PCH101
PE
FOXP3
Liquid
FOXP3
IgG2a, kappa
25 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
102120882, 50943, 574303, 740909
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