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FR4, Functional Grade, clone: eBioTH6, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-5446-85

Additional Details : Weight : 0.01000kg

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Product Code. 15248647

  • 3850.00 SEK / 500µg


EU Stock 1
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Description

Description

Description: The monoclonal antibody eBioTh6 recognizes FR4, also known as FR delta and FBP3 (folate binding protein3). FR4 is a heavily glycosylated 35 kD receptor for folic acid and the physiologic circulating form of the vitamin, N5-methyltetrahydrofolate. Natural T regs have high levels of FR4 and together with CD25 can be used to distinguish natural Tregs, effector T cells, memory-like T cells and naive T cells. In vivo studies with eBioTH6 show a decrease in the number of CD4+CD25+ cells and an enhanced tumor response leading to the elimination of advanced stages of tumors. Based on co-staining studies, the epitopes recognized by eBioTH6 and eBio12A5 (cat 51-5445) are different thereby allowing functional studies with TH6 to be evaluated with eBio12A5.Applications Reported: This eBioTH6 antibody has been reported for use in flow cytometric analysis, immunoprecipitation and in vivo depletion.Applications Tested: This eBioTH6 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay.Storage and handling: Use in a sterile environment.Filtration: 0.2μm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.
Specifications

Specifications

FR4
Monoclonal
1mg/mL
PBS with no preservative; pH 7.2
Q9EQF4
Folate receptor 4, FOLR4 FRdelta, FRd
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Murine
Flow Cytometry, Functional Assay, Immunoprecipitation
eBioTH6
Functional Grade
Izumo1r
Liquid
Izumo1r
IgG2b, kappa, kappa
500μg
Store at 2-8°C.
Primary
64931
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