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FR4, Functional Grade, clone: eBioTH6, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-5446-85

Additional Details : Weight : 0.01000kg

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Product Code. 15248647

  • 3850.00 SEK / 500µg


EU Stock 1
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Description

Description

Description: The monoclonal antibody eBioTh6 recognizes FR4, also known as FR delta and FBP3 (folate binding protein3). FR4 is a heavily glycosylated 35 kD receptor for folic acid and the physiologic circulating form of the vitamin, N5-methyltetrahydrofolate. Natural T regs have high levels of FR4 and together with CD25 can be used to distinguish natural Tregs, effector T cells, memory-like T cells and naive T cells. In vivo studies with eBioTH6 show a decrease in the number of CD4+CD25+ cells and an enhanced tumor response leading to the elimination of advanced stages of tumors. Based on co-staining studies, the epitopes recognized by eBioTH6 and eBio12A5 (cat 51-5445) are different thereby allowing functional studies with TH6 to be evaluated with eBio12A5.Applications Reported: This eBioTH6 antibody has been reported for use in flow cytometric analysis, immunoprecipitation and in vivo depletion.Applications Tested: This eBioTH6 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay.Storage and handling: Use in a sterile environment.Filtration: 0.2μm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.
Specifications

Specifications

FR4
Monoclonal
1mg/mL
PBS with no preservative; pH 7.2
Q9EQF4
Folate receptor 4, FOLR4 FRdelta, FRd
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Murine
Flow CytometryþFunctional AssayþImmunoprecipitation
eBioTH6
Functional Grade
Izumo1r
Liquid
Izumo1r
IgG2b, kappa, kappa
500μg
Store at 2-8°C.
Primary
64931
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