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Invitrogen™ Human FRAP1 (mTOR), GST Tag Recombinant Protein
Recombinant Protein
Brand: Invitrogen™ PV4753
This item is not returnable.
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Description
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Catalytic Assay Entry: Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical binding/kinetic System Compatibility: LanthaScreen™ Antibody, LanthaScreen™ Substrate, Z'-LYTE™
FRAP1 (mTOR) is a serine/threonine kinase that plays a critical role in cellular growth and proliferation. Perturbations in the mTOR/PI3-kinase/AKT pathway are associated with numerous forms of cancer. FRAP1 is also the target of rapamycin and its analogues, which are currently used as immunosuppressants and cancer therapeutics. Mutations affecting the gene results in Smith-Kingsmore syndrome.
Specifications
| P42345 | |
| Kinase Assay | |
| 2475 | |
| Human FRAP1 (mTOR), GST Tag | |
| 2610315D21Rik; AI327068; angiopoietin-like factor CDT6; FK506 binding protein 12-rapamycin associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; FKBP12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein; FKBP-rapamycin associated protein (FRAP); FKBP-rapamycin-associated protein FRAP; flat; FRAP; FRAP1; FRAP2; Mammalian target of rapamycin; mechanistic target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); mechanistic target of rapamycin kinase; Mtor; m-TOR; mTORC1; Raft1; Rapamycin and FKBP12 target 1; rapamycin and FKBP12 target-1 protein; rapamycin associated protein FRAP2; rapamycin target protein 1; RAPT1; serine/threonine-protein kinase mTOR; SKS | |
| PIKK Kinase Family | |
| Unconjugated | |
| Recombinant | |
| -80°C, Avoid Freeze/Thaw Cycles | |
| Ser⁄Thr Kinases: Atypical | |
| LanthaScreen™ Antibody, LanthaScreen™ Substrate, Z'-LYTE™ | |
| FK506 binding protein 12-rapamycin associated protein 1 | |
| Kinases & Inhibitors | |
| Liquid | |
| Signal Transduction, Drug Development, Oncology |
| See Label | |
| 50 mM tris with 0.1% polysorbate 20, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5 | |
| 163.9 kDa | |
| 10 μg | |
| mTOR | |
| 1360-2549 | |
| Human | |
| GST-tag | |
| Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical binding/kinetic | |
| Dry Ice | |
| mTOR, FRAP1 | |
| Insect cells | |
| Recombinant, Catalytic | |
| Serine/Threonine Kinases |
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