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STEMCELL Technologies GANT61

Produktkod. 17150262
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10 mg
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Produktkod. Kvantitet
17150262 10 mg
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Produktkod. 17150262 Leverantör STEMCELL Technologies Leverantörsnummer 73692

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Beskrivning

Hedgehog pathway inhibitor; Inhibits GLI

  • GANT61 is a hexahydropyrimidine derivative which selectively inhibits GLI transcription factors in the Hedgehog signaling pathway
  • GANT61 acts downstream of Smoothened to inhibit both GLI1- and GLI2-mediated transcription (IC50 = 5 μM in a GLI-transfected cell line) by preventing their DNA binding (Lauth et al.)
  • Inhibits in vitro proliferation of cancer cell lines (PANC1 and 22Rv1) with elevated GLI1 levels, and prevents the development of 22Rv1 tumors in mice (Lauth et al.)
  • Inhibits pancreatic cancer stem cell growth in vitro and in mouse xenograft model (Fu et al.)
  • Induces cell death of primitive neuroectodermal tumor cell line in a caspase-independent manner by inhibiting DNA replication (Matsumoto et al.)
  • Causes apoptosis in myeloid leukemia cells and in some cell lines is more effective when combined with rapamycin (Pan et al.)

Specifikationer

CAS 500579-04-4
Synonym NSC 136476
Kvantitet 10 mg
Molekylformel C27H35N5
Renhet ≥98%
Produkttitel
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