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Tocris Bioscience™ Gedunin

Produktkod. 18762734
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Kvantitet:
2 mg
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Produktkod. Kvantitet
18762734 2 mg
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Produktkod. 18762734 Leverantör Tocris Bioscience™ Leverantörsnummer 3387/2

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Beskrivning

Hsp90 inhibitor; exhibits anticancer and antimalarial activity

Gedunin is a naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro(IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Decreases ovarian cancer cell proliferation in vitroand may enhance cisplatin -induced reduction in proliferation (CAT.No 3387). Also exhibits antimalarial activity against Plasmodium falciparum(IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively).
TRUSTED_SUSTAINABILITY

Specifikationer

Kemiskt namn eller material (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione
CAS 2753-30-2
Kvantitet 2 mg
Mål HSP90 Inhibitors
Molekylformel C28H34O7
Renhet 0.98
Produkttitel
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