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  6. Geldanamycin, 98+%

Geldanamycin, 98+%

Produktkod. 15425649
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Produktkod. 15425649 Leverantör Thermo Scientific Alfa Aesar Leverantörsnummer J63397.MD
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Beskrivning

Benzoquinoid antibiotic that inhibits pp60src tyrosine kinase | CAS: 30562-34-6 | C29H40N2O9 | 560.644 g/mol

Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

Solubility
Soluble in dimethyl sulfoxide at 100 mg/mL.

Notes
Store in a cool dry place. Keep away from oxidizing agents. Protect from heat.
TRUSTED_SUSTAINABILITY

Chemische Identifikatoren

CAS 30562-34-6
Molekylformel C29H40N2O9
Molekylvikt (g/mol) 560.644
MDL-nummer MFCD00274570
InChI-nyckel QTQAWLPCGQOSGP-KDFVLELPSA-N
Synonym NSC 122750; U-29135
PubChem CID 133688416
IUPAC-namn [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
LEDER CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC

Spezifikation

Kemiskt namn eller material Geldanamycin
Typ Geldanamycin
Fysisk form Powder
Färg Orange to Yellow
Kvantitet 250 mg
Löslighetsinformation Soluble in dimethyl sulfoxide at 100mg/mL.
Formel vikt 560.64
Procent renhet ≥99%

RUO – Research Use Only

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