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Tocris Bioscience™ GSK 2837808A
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Produktkod. 18767058
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10mg
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18767058 10mg
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Produktkod. 18767058 Leverantör Tocris Bioscience™ Leverantörsnummer 5189/10

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Beskrivning

Potent and selective LDHA inhibitor

GSK 2837808A is a potent and selective lactate dehydrogenase A and B (LDHA and LDHB) inhibitor (IC50 values are 2.6 and 43 nM for LDHA and LDHB respectively). Inhibits lactate production in selected cancer cell lines. Reduces glucose uptake and enhances mitochondrial oxygen consumption in Snu398 hepatocellular carcinoma cells. Inhibits proliferation and induces apoptosis in Snu398 cells. Inhibits transcription of histone 2B (H2B) gene in HCT116 and NCM460 cells. Cell permeable.
TRUSTED_SUSTAINABILITY

Specifikationer

CAS 1445879-21-9
Kvantitet 10 mg
Molekylformel 3-[[3-[(Cyclopropylamino)sulfonyl]-7-(2,4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3,5-difluorophenoxy)benzoic acid
Produkttyp GSK 2837808A
Renhet 98%
Molekylvikt (g/mol) M.W. (Observed): 649.62
Inhibitorer GSK 2837808A

For Research Use Only

Produkttitel
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