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STEMCELL Technologies GSK621

Name: STEMCELL Technologies GSK621
Brand: STEMCELL Technologies
SKU: 17199981
Price: 1259.51 EUR

AMPK agonist

Brand: STEMCELL Technologies 100-0265

Additional Details : Weight : 0.05000kg

Product Code. 17199981

Estimated Shipment: 09-06-2023
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Description

GSK621 is a specific agonist of AMP-activated protein kinase (AMPK; Sujobert et al.)
Increases AMPKα T172 phosphorylation, a marker of AMPK activation, in acute myeloid leukemia (AML) cells and primary AML samples (Sujobert et al.)
Displays selective cytotoxicity (IC₅₀ = 13 - 30 μM) by activating autophagy via the eIF2ɑ signaling pathway independent of mTORC1 activation in AML cell lines but not in normal hematopoietic progenitor cells (Sujobert et al.)
Inhibits human melanoma cell survival and proliferation (Chen et al.)

Specifications

Description