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hamartin Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
1236.20 SEK - 3313.85 SEK
Specifications
Antigen | hamartin |
---|---|
Concentration | 0.4 mg/mL |
Applications | Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunofluorescence |
Classification | Polyclonal |
Conjugate | Unconjugated |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
16890575
|
Proteintech
20988-1-AP-20UL |
20 μL |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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16880575
|
Proteintech
20988-1-AP-150UL |
150 μL |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
This antibody can recognize two isoforms: 70 kDa (667aa) and 130 kDa.
Tuberous sclerosis complex (TSC) is an autosomal domit tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown.Specifications
hamartin | |
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunofluorescence | |
Unconjugated | |
Rabbit | |
Human, Mouse, Rat | |
Q92574, Q9EP53, Q9Z136 | |
60445, 64930, 7248 | |
Peptide | |
Primary | |
-20°C | |
TSC1 |
0.4 mg/mL | |
Polyclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Hamartin, KIAA0243, LAM, TSC, TSC1, tuberous sclerosis 1, Tuberous sclerosis 1 protein | |
Tsc1 | |
IgG | |
Antigen Affinity Chromatography | |
Antibody |