Invitrogen™ HAPLN4 Polyclonal Antibody

Beskrivning

Peptide sequence: NYGYRHNAEE RYDAFCFTSN LPGRVFFLKP LRPVPFSGAA RACAARGAAV Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 79%.

Hyaluronan and proteoglycan link protein 4 (HAPLN4), also known as Brain Link Protein 4 (BRAL1), is a gene located on chromosome 5q14.2, encoding a member of the link protein family that plays a crucial role in stabilizing interactions between hyaluronan and proteoglycans within the extracellular matrix. HAPLN4 is predominantly expressed in the brain, especially within the central nervous system where it contributes to the structural integrity and functional modulation of neural tissues. The protein is key in maintaining the organization of the extracellular matrix by binding hyaluronan and other matrix components, facilitating cell adhesion and signaling. This is vital for processes like neuronal migration, synapse formation, and neuronal differentiation during brain development. Variations in HAPLN4 expression or function are associated with neural developmental disorders and may influence the progression of neurodegenerative diseases due to its critical role in preserving the extracellular matrix architecture and neural connectivity.