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Invitrogen™ HES6 Polyclonal Antibody

Produktkod. 15574282
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Kvantitet:
100 μL
Förpackningsstorlek:
100µL
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Produktkod. Kvantitet unitSize
15574282 100 μL 100µL
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Produktkod. 15574282 Leverantör Invitrogen™ Leverantörsnummer PA540617

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Beskrivning

Rabbit Polyclonal Antibody

Peptide sequence: PPGPGDDLCS DLEEAPEAEL SQAPAEGPDL VPAALGSLTT AQIARSVWRP Sequence homology: Dog: 86%; Human: 100%; Mouse: 79%; Rat: 86%.

The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen HES6
Användningsområden Immunohistochemistry, Western Blot
Klassificering Polyclonal
Koncentration 1 mg/mL
Konjugera Unconjugated
Formulering PBS with 2% sucrose and 0.09% sodium azide
Gen HES6
Genaccessionsnr. Q96HZ4
Gene Alias AI326893; bHLHb41; bHLHc23; C-HAIRY1; class B basic helix-loop-helix protein 41; Hairy and enhancer of split 6; hes family bHLH transcription factor 6; hes6; HES-6; Transcription cofactor HES-6
Gensymboler HES6
Värd art Rabbit
Immunogen Synthetic peptide directed towards the C-terminal of human HES6 (aa 174-223).
Reningsmetod Protein A
Kvantitet 100 μL
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 55502
Målarter Human
Innehåll och lagring -20°C, Avoid Freeze/Thaw Cycles
Produkttyp Antibody
Form Liquid
Isotyp IgG
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