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HLA-DQ Mouse anti-Human, FITC, Clone: SK10, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-9881-41

Additional Details : Weight : 0.23750kg

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Product Code. 15576636

  • 796.00 SEK / 25 tests


Estimated Shipment
14-12-2020
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Description

Description

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Specifications

Specifications

HLA-DQ
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P01920
HLA-DQB1
IgG1, kappa
25 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
3119
Flow Cytometry
SK10
FITC
HLA-DQB1
Liquid
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
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