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HSD11B2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 14192-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16822724

  • 3313.85 SEK / 150µL
Estimated Shipment: 08-12-2021

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Description

Description

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
Specifications

Specifications

HSD11B2
0.23 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P50233, P51661, P80365
11 beta HSD2, 11 DH2, AME, AME1, HSD11B2, HSD11K, HSD2, SDR9C3
Rabbit
IgG
150 μL
-20°C
Primary
15484, 25117, 3291
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
HSD11B2
Liquid
HSD11B2
HSD11B2 Fusion Protein Ag5146
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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