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Gibco™ Human CCL25 (TECK), Animal-Free Recombinant Protein, PeproTech®

Produktkod. 17813313
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17813313 500 μg
17833523 100 μg
17813713 1 mg
17843243 20 μg
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Product Code. 17813313 Supplier Gibco™ Supplier No. AF30045500UG

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Description

Recombinant Protein

Recombinant Human TECK (CCL25) is a 14.2 kDa protein containing 127 amino acid residues, including the four conserved cysteine residues present in CC chemokines. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Chemokines are likely to play an important role in regulating the trafficking of developing T cells within the thymus. Chemokine C-C thymus expressed chemokine (TECK), also designated chemokine ligand 25 (CCL25), small induc-ible cytokine A25, chemokine b-15 or CK b-15, is expressed predominantly in thymic dendritic cells, thymic epithelial cells and in the small intestine. TECK, a CCR9 ligand, has suppressive activity against immature subsets of myeloid progenitors which have been stimulated to proliferate by multiple growth factors. TECK delivers signals through CCR9, which is important for the nav-igation of developing thymocytes. Bone marrow pre-pro-B cells and cells capable of generating pro-B colonies in the presence of interleukin-7 and Flt-3 ligand migrate to TECK, a response lost in later stages of B cell development.
TRUSTED_SUSTAINABILITY

Specifications

Tillträdesnummer O15444
För användning med (applikation) Functional Assay
Formulering protein with no preservative
Gen-ID (Entrez) 6370
Molekylvikt (g/mol) 14.2 kDa
Namn Human CCL25 (TECK), Animal-Free
Kvantitet 500 μg
Källa E. coli
Regulatorisk status RUO
Endotoxinkoncentration <0.1 EU/ μg
Gene Alias A130072A22Rik; AI852536; C-C motif chemokine 25; C-C motif chemokine ligand 25; CCL25; chemokine (C-C motif) ligand 25; chemokine TECK; Ck beta-15; CKb15; Scya25; SCYA25TECKvar; small inducible chemokine 25; small inducible cytokine A25; small inducible cytokine subfamily A (Cys-Cys), member 25; small-inducible cytokine A25; Teck; TECKMGC150327; TECKvar; thymus expressed chemokine; thymus-expressed chemokine
Vanligt namn TECK
Gensymbol CCL25
Biologisk aktivitet Determined by its ability to bind CCR9 receptor expressed on the surface of MOLT4 cells.
Konjugera Unconjugated
Rekombinant Recombinant
Sekvens QGVFEDCCLA YHYPIGWAVL RRAWTYRIQE VSGSCNLPAA IFYLPKRHRK VCGNPKSREV QRAMKLLDAR NKVFAKLHHN MQTFQAGPHA VKKLSSGNSK LSSSKFSNPI SSSKRNVSLL ISANSGL
Innehåll och lagring -20°C
Uttryckssystem E. coli
Form Lyophilized
Renhet eller kvalitetsklass ≥ 98% by SDS-PAGE gel and HPLC analyses.
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