missing translation for 'onlineSavingsMsg'
Läs mer
  1. Home
  2. Products
  3. Rekombinanta proteiner
  4. Gibco™ Human Dkk-1 Recombinant Protein

Gibco™ Human Dkk-1 Recombinant Protein

Produktkod. 10227904
Klicka för att se tillgängliga alternativ
Kvantitet:
1 mg
10 μg
100 μg
25 μg
Förpackningsstorlek:
Varje
Denna artikel kan inte returneras. Se returpolicy

For Research Use Only. All usage must comply with product instructions.

Produktkod. 10227904

Brand: Gibco™ PHC9211

Vänligen för att beställa denna produkten. Behöver du ett Webbkonto? Registrera ditt konto idag!

Denna artikel kan inte returneras. Se returpolicy

For Research Use Only. All usage must comply with product instructions.

Beskrivning

Recombinant Protein

Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile, distilled water to a concentration of 0.1-0.5 mg/mL. Apportion the reconstituted protein into working aliquots and store at ≤-20°C. Make any further dilutions of the reconstituted protein in low endotoxin medium or a buffered solution containing a carrier protein such as heat inactivated FCS or tissue culture grade BSA. Storage: Store the lyophilized protein at 2-8°C or -20°C long term, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤-20°C. Avoid repeated freeze-thaw cycles.

DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.
TRUSTED_SUSTAINABILITY

Specifikationer

Tillträdesnummer O94907
För användning med (applikation) Bioactivity
Formulering Protein with no preservative
Gen-ID (Entrez) 22943
Molekylvikt (g/mol) 42 kDa
Namn Human Dkk-1
Reningsmetod Purified
Kvantitet 100 μg
Förvaringskrav 4°C
Regulatorisk status RUO
Endotoxinkoncentration <0.1 ng/μg
Gene Alias dickkopf 1 homolog; dickkopf homolog 1; dickkopf homolog 1 (Xenopus laevis); dickkopf related protein-1; dickkopf WNT signaling pathway inhibitor 1; Dickkopf1; dickkopf-1; dickkopf-1 like; dickkopf-like protein 1; dickkopf-related protein 1; DKK1; DKK-1; hDkk1; hDkk-1; mdkk-1; SK; UNQ492/PRO1008
Vanligt namn DKK1
Gensymbol DKK1
Biologisk aktivitet ED50 ≤ 40 ng/mL; determined by the binding of immobilized human LRP6/Fc chimera receptro (3 μg/mL) to human Dkk-1 in. a functional ELISA.
Produkttyp Protein
Konjugera Unconjugated
Art Human
Rekombinant Recombinant
Innehåll och lagring 4°C
Klassificering Carrier-Free
Aktivitet ED50 ≤ 40 ng/mL; determined by the binding of immobilized human LRP6/Fc chimera receptro (3 μg/mL) to human Dkk-1 in a functional ELISA.
Endotoxinnivå <0.1 ng/μg
Reaktivitet Human
Frakt skick Wet Ice
Specifik aktivitet Linear range of 0.3 to 40 ng⁄ml
Uttryckssystem HEK293 cells
Proteinfamilj Cytokines & Receptors
Proteinform Recombinant, Ligand
Form Lyophilized
Protein subtyp Other Proteins
Forskningskategori Oncology, Signal Transduction
Produktlinje Gibco™
Renhet eller kvalitetsklass ≥95% by SDS-PAGE and HPLC
Visa mer Visa mindre
Korrigering av produktinnehåll

Din input är viktig för oss. Fyll i det här formuläret för att ge feedback relaterad till innehållet på denna produkt.

Produkttitel

Genom att klicka på Skicka bekräftar du att du kan bli kontaktad av Fisher Scientific angående feedbacken du har lämnat i detta formulär. Vi kommer inte att dela din information för andra ändamål. All kontaktinformation som tillhandahålls ska också underhållas i enlighet med vår Sekretesspolicy.

Tack! Din feedback har skickats. Fisher Scientific arbetar alltid för att förbättra vårt innehåll åt dig. Vi uppskattar din feedback.