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Gibco™ Human GDNF Recombinant Protein

Produktkod. 10679963 Handla allt Gibco Produkter
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Kvantitet:
1 mg
10 μg
100 μg
5 μg
Förpackningsstorlek:
Varje
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Produktkod. Kvantitet Förpackningsstorlek
10679963 10 μg Varje
10641504 100 μg Varje
10737683 1 mg Varje
10110633 5 μg Varje
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For Research Use Only. All usage must comply with product instructions.
Produktkod. 10679963 Leverantör Gibco™ Leverantörsnummer PHC7045
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For Research Use Only. All usage must comply with product instructions.

Beskrivning

Recombinant Protein

Carrier-Free Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute lyophilized human GDNF in sterile, distilled water to 0.1-0.5 mg/mL. These stock solutions should be apportioned into working aliquots and stored at ≤-20°C. Further dilution should be made in medium or buffered solution containing carrier protein, such as PBS with 0.1% BSA. Storage: Lyophilized human GDNF should be stored at 2°C to 8°C, preferably desiccated. Store reconstituted human GDNF at ≤-20°C (not in a frost-free freezer). Keep freeze-thaw cycles to a minimum.

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
TRUSTED_SUSTAINABILITY

Specifikationer

Tillträdesnummer P39905
För användning med (applikation) Bioactivity
Formulering Protein with no preservative
Gen-ID (Entrez) 2668
Molekylvikt (g/mol) 30.1 kDa
Namn Human GDNF
Reningsmetod Purified
Kvantitet 10 μg
Förvaringskrav 4°C
Regulatorisk status RUO
Endotoxinkoncentration <0.1 ng/μg
Gene Alias AI385739; Astrocyte-derived trophic factor; ATF; ATF1; ATF2; Gdnf; glial cell derived neurotrophic factor; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; glial cell line-derived neurotrophic factor; gndf; HFB1-GDNF; hGDNF; H-GDNF; HSCR3; mGDNF; neurotrophic factor
Vanligt namn GDNF
Gensymbol GDNF
Biologisk aktivitet ED50 ≤ 10 n/mL; determined by the dose-dependent neurite outgrowth of PC-12 cells in the presence of soluble GFR-alpha.
Produkttyp Protein
Konjugera Unconjugated
Art Human
Rekombinant Recombinant
Sekvens SPDKQMAVLP RRERNRQAAA ANPENSRGKG RRGQRGKNRG CVLTAIHLNV TDLGLGYETK EELIFRYCSG SCDAAETTYD KILKNLSRNR RLVSDKVGQA CCRPIAFDDD LSFLDDNLVY HILRKHSAKR CGCI
Innehåll och lagring 4°C
Klassificering Carrier-Free
Aktivitet ED50 ≤ 10 n/mL; determined by the dose-dependent neurite outgrowth of PC-12 cells in the presence of soluble GFR-alpha.
Endotoxinnivå <0.1 ng/μg
Frakt skick Approved for shipment on Wet or Dry Ice
Uttryckssystem E. coli
Proteinfamilj Growth Factors & Receptors
Proteinform Recombinant, Ligand
Form Lyophilized
Protein subtyp Neurotrophic Factors
Forskningskategori Neurobiology, Stem Cell Research, Differentiation
Produktlinje Gibco
Renhet eller kvalitetsklass >98% by SDS-PAGE
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