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Gibco™ Human GDNF Recombinant Protein, PeproTech®

Produktkod. 17874173
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Produktkod. Kvantitet Förpackningsstorlek
17874173 10 μg 10µg
17814073 100 μg -
17894713 1 mg -
17814463 250 μg -
17824723 2 μg -
17874643 500 μg -
17874303 50 μg 50µg
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Produktkod. 17874173 Leverantör Gibco™ Leverantörsnummer 4501010UG
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Beskrivning

Recombinant Protein

The functional human GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine-knot configuration. The calculated molecular weight of Recombinant Human GDNF is 30.4 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
TRUSTED_SUSTAINABILITY

Specifikationer

Tillträdesnummer P39905
För användning med (applikation) Bioactivity, Control, Western Blot Control
Formulering Protein with no preservative
Gen-ID (Entrez) 2668
Molekylvikt (g/mol) 30.4 kDa
Namn Human GDNF
Reningsmetod Purified
Kvantitet 10 μg
Källa E. coli
Förvaringskrav -20°C
Regulatorisk status RUO
Endotoxinkoncentration <1 EU/μg
Gene Alias AI385739; Astrocyte-derived trophic factor; ATF; ATF1; ATF2; Gdnf; glial cell derived neurotrophic factor; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; glial cell line-derived neurotrophic factor; gndf; HFB1-GDNF; hGDNF; H-GDNF; HSCR3; mGDNF; neurotrophic factor
Vanligt namn GDNF
Gensymbol GDNF
Biologisk aktivitet Determined by a cell proliferation assay using SH-SY5Y cells. The expected ED50 for this effect is 1.0-10.0 ng/ml
Produkttyp Protein
Konjugera Unconjugated
Rekombinant Recombinant
Sekvens MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI
Innehåll och lagring -20°C
Aktivitet Determined by a cell proliferation assay using SH-SY5Y cells. The expected ED50 for this effect is 1.0-10.0 ng/ml.
Uttryckssystem E. coli
Form Lyophilized
Renhet eller kvalitetsklass ≥ 98% by SDS-PAGE gel and HPLC analyses.
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