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Invitrogen™ eBioscience™ Human Brain-Derived Neurotrophic Factor (BDNF), Recombinant Protein

Produktkod. 15517536
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Kvantitet:
25μg
Förpackningsstorlek:
25µg
Denne vare kan ikke returneres. Se returpolicy

Artikelnummer. 15517536

Brand: Invitrogen™ 14836680

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Human Recombinant Protein

Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, proBDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation.
TRUSTED_SUSTAINABILITY

Tekniske data

Tillträdesnummer NM_001709
Koncentration 0.1mg/mL
För användning med (applikation) Cytokine Bioassay
Formulering Sterile liquid; 20mM NaCitrate, 300mM NaCl, 1% BSA, pH 4.0, 0.22μm filtered
Molekylvikt (g/mol) 15.4kDa
Namn Brain-Derived Neurotrophic Factor (BDNF)
Reningsmetod SDS-PAGE
Kvantitet 25μg
Källa E. coli
Förvaringskrav Store at less than or equal to -70°C.
Regulatorisk status RUO
Strukturell form E. coli expressed amino acids His129-Arg247 accession number NM_001709
Endotoxinkoncentration Less than 0.01ng/μg cytokine as determined by the LAL assay.
Gensymbol Brain-Derived Neurotrophic Factor
Biologisk aktivitet The ED50 of this protein, as measured by proliferation of C6 cells, is less than or equal to 100ng/mL. This corresponds to a specific activity of greater than or equal to 1 x 104 Units/mg.
Produkttyp Recombinant Protein
Konjugera Unconjugated
Korsreaktivitet Human
Rekombinant Recombinant
Renhet eller kvalitetsklass ≥97%
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