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Gibco™ Human IL-10 Recombinant Protein, PeproTech®
Recombinant Protein
852.00 SEK - 55400.00 SEK
Specifications
| Accession Number | P22301 |
|---|---|
| For Use With (Application) | ELISA, Functional Assay, Western Blot |
| Formulation | protein with no preservative |
| Gene ID (Entrez) | 3586 |
| Molecular Weight (g/mol) | 18.6 kDa |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
17830513
|
Gibco™
200-10-100UG |
100 μg |
11100.00 SEK
100µg |
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|
17890563
|
Gibco™
200-10-10UG |
10 μg |
2100.00 SEK
10µg |
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|
17821303
|
Gibco™
200-10-1MG |
1 mg |
55400.00 SEK
1mg |
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|
17880333
|
Gibco™
200-10-250UG |
250 μg |
19420.00 SEK
250µg |
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|
17861073
|
Gibco™
200-10-2UG |
2 μg |
852.00 SEK
2µg |
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|
17800523
|
Gibco™
200-10-500UG |
500 μg |
33170.00 SEK
500µg |
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|
17891073
|
Gibco™
200-10-50UG |
50 μg |
6680.00 SEK
50µg |
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Description
Recombinant Human IL-10 is an 18.6 kDa protein of 161 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.Specifications
| P22301 | |
| protein with no preservative | |
| 18.6 kDa | |
| E. coli | |
| <1 EU/ μg | |
| IL-10 | |
| Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED50 was found to be ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg | |
| Recombinant | |
| -20°C | |
| Lyophilized |
| ELISA, Functional Assay, Western Blot | |
| 3586 | |
| Human IL-10 | |
| RUO | |
| CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF | |
| IL10 | |
| Unconjugated | |
| MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N | |
| E. coli | |
| ≥ 98% by SDS-PAGE gel and HPLC analyses. |
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