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Invitrogen™ Human LAG-3 (CD223) Fc Chimera Recombinant Protein

Produktkod. 17986261
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17986261 500 μg
17965861 50 μg
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Produktkod. 17986261 Leverantör Invitrogen™ Leverantörsnummer RP88096
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    15290.00 SEK
    14678.40 SEK / 500µg
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Beräknad leverans: 15-12-2026
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Beskrivning

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (330 μL) be added to the vial to prepare a stock solution of 0.15 mg/mL. Concentration is measured by UV.

LAG-3 is a 70-kDa surface glycoprotein in the immunoglobulin superfamily, with structural homology to CD4. It binds to MHC class II molecules with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation. LAG-3 is expressed on the surface of activated T cells, including regulatory T cells, and NK cells. Notably, CD8+ T cells express LAG-3 at significantly higher levels than CD4+ T cells. Additionally, the coexpression of LAG-3 and CD49b has been proposed as a marker for identifying Type 1 regulatory T cells (Tr1 cells) in both humans and mice. This highlights LAG-3s role in immune regulation and its potential as a target for therapeutic interventions in immune-related conditions.
TRUSTED_SUSTAINABILITY

Specifikationer

Tillträdesnummer P18627
För användning med (applikation) Binding Assay, Control, ELISA Standard
Formatera Lyophilized
Formulering PBS with 15% trehalose and no preservative; pH 7.4
Gen-ID (Entrez) 3902
Molekylvikt (g/mol) 72.58 kDa
Namn Human LAG-3 (CD223) Fc Chimera
pH-intervall 7.4
Reningsmetod Purified
Kvantitet 500 μg
Förvaringskrav -20°C, Avoid Freeze/Thaw Cycles
Regulatorisk status RUO
Endotoxinkoncentration <1.0 EU/μg
Gene Alias Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; LAG3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3
Vanligt namn LAG-3 (CD223)
Gensymbol LAG3
Biologisk aktivitet Immobilized LAG3 Protein, Human, Recombinant (ECD, mFc Tag) (at 2 μg/mL (100 μL/well) can bind Anti-LAG3 (BMS)-IgG4 Antibody (Relatlimab), the EC50 is 8-40 ng/mL)
Produkttyp Protein
Konjugera Unconjugated
Rekombinant Recombinant
Protein Tag Fc-tag
Sekvens Human LAG3, amino acids Met1-Leu450 (Accession # NP_002277.4) with a C-terminal mouse IgG1 Fc region
Innehåll och lagring -20°C, Avoid Freeze/Thaw Cycles
Aktivitet Immobilized LAG3 Protein, Human, Recombinant (ECD, mFc Tag) at 2 μg/mL (100 μL/well) can bind Anti-LAG3 (BMS)-IgG4 Antibody (Relatlimab), the EC50 is 8-40 ng/mL.
Uttryckssystem HEK293 cells
Form Lyophilized
Renhet eller kvalitetsklass ≥90% as determined by SDS-PAGE.
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