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Invitrogen™ Human LSD1 Synthetic Peptide

Produktkod. 15266549
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Kvantitet:
50 μg
Förpackningsstorlek:
50µg
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15266549 50 μg 50µg
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Produktkod. 15266549 Leverantör Invitrogen™ Leverantörsnummer PEP0339
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Beräknad leverans: 24-08-2026
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Beskrivning

Synthetic Peptide

This peptide corresponds to 17 amino acids near the amino terminus of human LSD1. PEP-0339 can be used as a blocking peptide with polyclonal antibody PA5-20226.

LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.
TRUSTED_SUSTAINABILITY

Specifikationer

Gen-ID (Entrez) 23028
Art Human
Reningsmetod purified
Tillträdesnummer O60341
Vanligt namn LSD1
Koncentration 200 μg/mL
Innehåll och lagring -20°C
Beskrivning Synthetic Peptide
Formatera Liquid
Formulering PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
För användning med (applikation) Blocking Assay, Control
Gene Alias 1810043O07Rik; AA408884; amine oxidase (flavin containing) domain 2; AOF2; BHC110; BRAF35-HDAC complex protein BHC110; CPRF; D4Ertd478e; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; flavin-containing amine oxidase domain-containing protein 2; KDM1; KDM1A; KIAA0601; Lsd1; lysine (K)-specific demethylase 1; lysine (K)-specific demethylase 1A; lysine demethylase 1A; lysine-specific demethylase 1; lysine-specific histone demethylase 1; lysine-specific histone demethylase 1A; mKIAA0601; neuroprotective protein 3; RGD1562975; RP1-184J9.1; wu:fb82e06; wu:fc51a02; wu:fj36a05; wu:fj66b06
Gensymbol KDM1A
Frystorkat material No
Konserveringsmedel Sodium azide
Produkttyp Peptide
Kvantitet 50 μg
Regulatorisk status RUO
Förvaringsbuffert PBS
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