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Gibco™ Human M-CSF Recombinant Protein, PeproTech®

Recombinant Protein

880.00 SEK - 47220.00 SEK

Specifica

Accession Number P09603
For Use With (Application) ELISA, Functional Assay, Western Blot
Formulation protein with no preservative
Gene ID (Entrez) 1435
Molecular Weight (g/mol) 36.8 kDa
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Prodotti 7
Codice del prodotto Marca Quantity Prezzo QuantitĂ  e disponibilitĂ   
Codice del prodotto Marca Quantity Prezzo QuantitĂ  e disponibilitĂ   
17862143
missing translation for 'viewDocuments' Dettagli della promozione
Gibco™
300-25-100UG
100 ÎĽg
9410.00 SEK
100µg
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17882763
missing translation for 'viewDocuments' Dettagli della promozione
Gibco™
300-25-10UG
10 ÎĽg
2165.00 SEK
10µg
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17882543
missing translation for 'viewDocuments' Dettagli della promozione
Gibco™
300-25-1MG
1 mg
47220.00 SEK
1mg
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17832463
missing translation for 'viewDocuments' Dettagli della promozione
Gibco™
300-25-250UG
250 ÎĽg
16560.00 SEK
250µg
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17882943
missing translation for 'viewDocuments' Dettagli della promozione
Gibco™
300-25-2UG
2 ÎĽg
880.00 SEK
2µg
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17882053
missing translation for 'viewDocuments' Dettagli della promozione
Gibco™
300-25-500UG
500 ÎĽg
28260.00 SEK
500µg
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17852253
missing translation for 'viewDocuments' Dettagli della promozione
Gibco™
300-25-50UG
50 ÎĽg
5670.00 SEK
50µg
Please to purchase this item. Need a web account? Register with us today!
Descrizione

Descrizione

Recombinant Human M-CSF is a 36.8 kDa homodimeric protein consisting of two 159 amino acid polypeptide subunits. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

M-CSF (Macrophage colony-stimulating factor, CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization. M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. Further, M-CSF is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex. Functionally, M-CSF is known to stimulate differentiation of hematopoietic stem cells to monocyte-macrophage cell populations in culture. M-CSF acts through the CSF receptor 1. Although human M-CSF shows activity on mouse cells, mouse CSF shows no activity on human cells.
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Gibco™ Human M-CSF Recombinant Protein, PeproTech®

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