Invitrogen™ MCP-1 Human ELISA Kit
For the quantitative detection of human MCP-1.
Brand: Invitrogen™ BMS281TEN
Additional Details : Weight : 0.23750kg
DescriptionMCP-1 (Monocyte chemotactic protein-1, CCL2) has a predicted molecular weight of approximately 11kDa, however, it may run at a higher molecular weight due to glycosylation. MCP-1 is a member of the cytokine family and plays an important role in immunoregulation and inflammatory processes. MCP-1 signals through G protein-coupled receptors, CCR2 and CCR4, to recruit memory T cells, monocytes and dendritic cells. MCP-1 is linked with tumor progression, angiogenesis, and displays selective chemotactic activity towards monocytes and basophils but not neutrophils or eosinophils. MCP-1 is produced by a variety of cell types and is a potent chemoattractant for monocytes, memory T lymphocytes, and natural killer (NK) cells. Further, MCP-1 is indicated in the etiology of several immune disorders, and is upregulated during infection and inflammation. While MCP-1 is a potent basophil activator, the related protein MCP-2 stimulates both eosinophils and basophils. MCP-3 has been shown to have the broadest range of influence. MCP-1 has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis.
|Amniotic Fluid, 20 μL|Plasma, 20 μL|Serum, 20 μL|Supernatant, 20 μL|
|1 hr. 20 min.|
|Monocyte chemoattractant protein 1, MCAF, HC11|
|Pre-coated 96 well plate, Standard, Sample Diluent, Assay Buffer concentrate, HRP-conjugated Detection Antibody, Wash Buffer, Chromogen, Stop Solution, Controls, Adhesive Plate Covers|
|2°C to 8°C|
|2 hr. 10 min.|
|10 x 96 Tests|
|Colorimetric Microplate Reader|
For Research Use Only