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Gibco™ Human MIP-1 beta (CCL4) Recombinant Protein, PeproTech®

Produktkod. 17820533
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17820533 2 μg
17801703 100 μg
17811623 10 μg
17840343 1 mg
17840353 250 μg
17891203 500 μg
17851893 50 μg
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Produktkod. 17820533 Leverantör Gibco™ Leverantörsnummer 300092UG

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Beskrivning

Recombinant Protein

Recombinant Human MIP-1beta is a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family. Functionally, CCL4 is involved in chemotactic and proinflammatory effects, and homeostasis. CCL4 is produced by macrophages upon stimulation by bacterial endotoxins. CCL4 recruits and stimulates various inflammatory cells at sites of inflammation. CCL4 is produced by lymphocytes, macrophages and dendritic cells. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ, with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells. CCL4 binds with high affinity to CCR5 receptors.
TRUSTED_SUSTAINABILITY

Specifikationer

Tillträdesnummer P13236
För användning med (applikation) Control, Western Blot Control, ELISA Standard, Bioactivity
Formulering Protein with no preservative
Gen-ID (Entrez) 6351
Molekylvikt (g/mol) 7.6 kDa
Namn Human MIP-1 beta (CCL4)
Reningsmetod Purified
Kvantitet 2 μg
Källa E. coli
Förvaringskrav -20°C
Regulatorisk status RUO
Endotoxinkoncentration <1 EU/μg
Gene Alias ACT2; ACT-2; AT744.1; CC chemokine ligand 4; C-C motif chemokine 4; C-C motif chemokine ligand 4; Ccl4; chemokine (C-C motif) ligand 4; G-26; G-26 T-lymphocyte-secreted protein; HC21; immune activation gene 2; immune activation gene-2; immune activation protein 2; LAG1; LAG-1; Lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; macrophage inflammatory protein-1 beta; MGC104418; MGC126025; MGC126026; MIP-1 beta; MIP1b; MIP-1B; Mip1-b; MIP1B1; MIP1beta; MIP-1BETA; MIP-1-beta; MIP1-beta; MIP-1-beta(1-69); MIP-1-beta(3-69); PAT 744; Protein H400; putative MIP-1beta protein; RP23-320E6.8; SCY4A; SCYA2; Scya4; secreted protein G-26; SIS-gamma; small inducible cytokine A4; small inducible cytokine A4 (homologous to mouse Mip-1b); small-inducible cytokine A4; T-cell activation protein 2
Vanligt namn CCL4
Gensymbol CCL4
Biologisk aktivitet Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml
Produkttyp Protein
Konjugera Unconjugated
Rekombinant Recombinant
Sekvens APMGSDPPTA CCFSYTARKL PHNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN
Innehåll och lagring -20°C
Aktivitet Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml.
Uttryckssystem E. coli
Form Lyophilized
Renhet eller kvalitetsklass ≥ 98% by SDS-PAGE gel and HPLC analyses.
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