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Gibco™ Human/Mouse/Rat BDNF Recombinant Protein, PeproTech®

Produktkod. 17874463
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17874463 100 μg 100µg
17834733 10 μg 10µg
17824183 1 mg -
17894313 250 μg -
17854143 2 μg -
17854253 500 μg -
17874523 50 μg 50µg
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Produktkod. 17874463 Leverantör Gibco™ Leverantörsnummer 45002100UG

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8784.00 SEK valid until 2026-06-30
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Beskrivning

Recombinant Protein

Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.
TRUSTED_SUSTAINABILITY

Specifikationer

Tillträdesnummer P21237, P23363, P23560
För användning med (applikation) ELISA, Functional Assay, Western Blot
Formulering protein with no preservative
Gen-ID (Entrez) 12064, 24225, 627
Molekylvikt (g/mol) 27 kDa
Namn Human/Mouse/Rat BDNF
Kvantitet 100 μg
Källa E. coli
Regulatorisk status RUO
Endotoxinkoncentration <1 EU/ μg
Gene Alias abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; bdnf protein; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; H-BDNF; neurotrophin; ProBDNF
Vanligt namn BDNF
Gensymbol BDNF
Biologisk aktivitet Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Konjugera Unconjugated
Rekombinant Recombinant
Sekvens MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Innehåll och lagring -20°C
Uttryckssystem E. coli
Form Lyophilized
Renhet eller kvalitetsklass ≥ 98% by SDS-PAGE gel and HPLC analyses.
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