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STEMCELL Technologies Human Recombinant IL-10
Interleukin 10
Brand: STEMCELL Technologies 78024.1
Additional Details : Weight : 0.00110kg
Description
- Interleukin 10 (IL-10) is the founding member of the IL-10 family of class II cytokines
- All of the IL-10 cytokine family members have a four-helix bundle consisting of α-helical folds
- Upon binding to its receptor, IL-10 activates signaling through JAK1 and STAT3
- It is produced by dendritic cells, macrophages, and CD4+ T cells, as well as mast cells, NK cells, neutrophils, and B cells, under specific stimulating conditions (Saraiva & O'Garra)
- IL-10 can inhibit the expression of pro-inflammatory cytokines and promote healing processes, and is important for the function of regulatory T cells
- IL-10 also enhances B cell proliferation, immunoglobulin secretion, and class II MHC expression, while IL-10 produced by macrophages inhibits activation of neighboring macrophages, thus allowing a level of self-regulation (Ouyang et al.)
Specifications
| B-TCGF, CSIF, Cytokine synthesis inhibitory factor, Interleukin-10, TGIF | |
| ≥95% | |
| 10 μg | |
| Dendritic Cells; Hematopoietic Stem and Progenitor Cells; Myeloid Cells; Neurons; T Cells |