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  4. STEMCELL Technologies Human Recombinant LIF

STEMCELL Technologies Human Recombinant LIF

Product Code. 17109461
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Kvantitet:
10 μg
1000 μg
50 μg
This item is not returnable. View return policy

Product Code. 17109461

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This item is not returnable. View return policy

Description

Leukemia inhibitory factor

  • Leukemia inhibitory factor (LIF) is an interleukin 6 class cytokine that regulates a broad variety of developmental functions
  • After LIF binds to LIF receptor (LIFR), LIFR associates with gp130 and activates JAK/STAT and MAPK signaling
  • LIFR activation of STAT3 is essential for maintaining the mouse embryonic stem cell phenotype
  • Produced by the endometrium, LIF plays an important autocrine and paracrine role in implantation by regulating proliferation, invasion, and differentiation of trophoblasts following blastocyst attachment
  • Human LIF can be used for the maintenance of mouse embryonic stem cells, however mouse LIF cannot bind to the human receptor, thus rendering mouse LIF inactive
  • LIF is produced by CD4+ and activated regulatory T cells, and promotes Foxp3 expression, while repressing Th17 lineage-specific genes

Specifications

Namn CDF, Cholinergic differentiation factor, D Factor, DIA, Differentiation-inducing factor, Differentiation inhibitory activity, Differentiation-stimulating factor, Emfilermin, Hepatocyte-stimulating factor III, HILDA, Leukemia inhibitory factor, MLPLI
Kvantitet 10 μg
Celltyp Neural Cells, PSC-Derived; Neurons; Pluripotent Stem Cells
Renhet eller kvalitetsklass >95%
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