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STEMCELL Technologies Human Recombinant LIF
Leukemia inhibitory factor
Brand: STEMCELL Technologies 78055.1
This item is not returnable.
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Description
- Leukemia inhibitory factor (LIF) is an interleukin 6 class cytokine that regulates a broad variety of developmental functions
- After LIF binds to LIF receptor (LIFR), LIFR associates with gp130 and activates JAK/STAT and MAPK signaling
- LIFR activation of STAT3 is essential for maintaining the mouse embryonic stem cell phenotype
- Produced by the endometrium, LIF plays an important autocrine and paracrine role in implantation by regulating proliferation, invasion, and differentiation of trophoblasts following blastocyst attachment
- Human LIF can be used for the maintenance of mouse embryonic stem cells, however mouse LIF cannot bind to the human receptor, thus rendering mouse LIF inactive
- LIF is produced by CD4+ and activated regulatory T cells, and promotes Foxp3 expression, while repressing Th17 lineage-specific genes
Specifications
| CDF, Cholinergic differentiation factor, D Factor, DIA, Differentiation-inducing factor, Differentiation inhibitory activity, Differentiation-stimulating factor, Emfilermin, Hepatocyte-stimulating factor III, HILDA, Leukemia inhibitory factor, MLPLI | |
| 10 μg | |
| Neural Cells, PSC-Derived; Neurons; Pluripotent Stem Cells | |
| >95% |
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Product Title
STEMCELL Technologies Human Recombinant LIF
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