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Gibco™ Human TGF-beta 3 Recombinant Protein, PeproTech®
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Kvantitet:
1 mg
10 μg
100 μg
2 μg
250 μg
50 μg
500 μg
Beskrivning
Recombinant Human TGF-beta3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
Specifikationer
Specifikationer
| Tillträdesnummer | P10600 |
| För användning med (applikation) | ELISA, Functional Assay, Western Blot |
| Formulering | protein with no preservative |
| Gen-ID (Entrez) | 7043 |
| Molekylvikt (g/mol) | 25 kDa |
| Namn | Human TGF-beta 3 |
| Kvantitet | 10 μg |
| Källa | E. coli |
| Regulatorisk status | RUO |
| Endotoxinkoncentration | <1 EU/ μg |
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