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  4. ACROBiosystems Human TL1A / TNFSF15 Protein, His Tag (MALS verified)

ACROBiosystems Human TL1A / TNFSF15 Protein, His Tag (MALS verified)
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Produktkod. 17276580
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Kvantitet:
1 mg
100 μg
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17276580 100 μg
17286580 1 mg
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Produktkod. 17276580 Leverantör ACROBiosystems Leverantörsnummer TLAH5243100ug

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Beskrivning

TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals for activated lymphocytes. DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory T-cells. Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating T-cell activation and downregulating the secretion of pro-inflammatory cytokines. Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses.

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 22.4 kDa. The protein migrates as 26 kDa and 28-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifikationer

Tillträdesnummer NP_005109.2
Molekylvikt (g/mol) 22.4 kDa
Kvantitet 100 μg
Källa Human TL1A, His Tag (TLA-H5243) is expressed from human 293 cells (HEK293). It contains AA Leu 72- Leu 251 (Accession # O95150-1).
Immunogen Leu 72- Leu 251
Förvaringskrav -20°C
Gene Alias TL1A, VEGI-251, TNFSF15
Vanligt namn TL1A
Konjugera Unconjugated
Art Human
Protein Tag His Tag
Buffert PBS, pH7.4
Endotoxinnivå Less than 1.0 EU / μg by the LAL method.
Uttryckssystem HEK293
Form Powder
Protein subtyp Other Recombinant Proteins
Renhet eller kvalitetsklass >90% as determined by SDS-PAGE.
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