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Gibco™ Human TNF-alpha Recombinant Protein

Produktkod. 10394253
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10394253 100 μg Varje
10542435 1 mg Varje
10304263 10 μg Varje
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For Research Use Only. All usage must comply with product instructions.
Produktkod. 10394253 Leverantör Gibco™ Leverantörsnummer PHC3011

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For Research Use Only. All usage must comply with product instructions.

Beskrivning

Recombinant Protein

Carrier-Free.

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
TRUSTED_SUSTAINABILITY

Specifikationer

Tillträdesnummer P01375
För användning med (applikation) Bioactivity
Formulering Protein with no preservative
Gen-ID (Entrez) 7124
Molekylvikt (g/mol) 17.5 kDa
Namn Human TNF-alpha
Reningsmetod Purified
Kvantitet 100 μg
Förvaringskrav 4°C
Regulatorisk status RUO
Endotoxinkoncentration <0.1 ng/μg
Gene Alias APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF α; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFα; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
Vanligt namn TNF alpha
Gensymbol Tnf
Biologisk aktivitet ED50 < 0.05 ng/mL; determined by the dose-dependent cytotoxcity on L929 cells in the presence of actinomycin D.
Produkttyp Protein
Konjugera Unconjugated
Art Human
Rekombinant Recombinant
Sekvens VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL
Innehåll och lagring 4°C
Klassificering Carrier-Free
Aktivitet ED50 < 0.05 ng/mL; determined by the dose-dependent cytotoxcity on L929 cells in the presence of actinomycin D.
Endotoxinnivå <0.1 ng/μg
Frakt skick Wet Ice
Uttryckssystem E. coli
Proteinfamilj Cytokines & Receptors
Proteinform Recombinant, Ligand
Form Lyophilized
Protein subtyp TNF (Tumor Necrosis Factor)
Forskningskategori Immunology, Signal Transduction, Stem Cell Research, Inflammation, Oncology
Produktlinje Gibco
Renhet eller kvalitetsklass >95% by SDS-PAGE
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