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humanin Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 25885-1-AP-20UL
Additional Details : Weight : 0.00010kg
Description
Humanin is a novel 24 A. A polypeptide identified in Alzheimer′s disease-affected brain. It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor. It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer′s disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids. It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity. It activates JAK/STAT signaling pathway and is regulated by TRIM11. It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells. Humanin is also expressed in colon and testis.Specifications
humanin | |
Polyclonal | |
Unconjugated | |
MT-RNR2 | |
humanin, l rRNA, MTRNR2, RNR2 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
4550 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin) | |
0.41 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
Q8IVG9 | |
MT-RNR2 | |
Peptide | |
20 μL | |
Primary | |
Human | |
Antibody | |
IgG |