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humanin Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 25885-1-AP-20UL
Additional Details : Weight : 0.00010kg
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DescriptionHumanin is a novel 24 A. A polypeptide identified in Alzheimer′s disease-affected brain. It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor. It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer′s disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids. It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity. It activates JAK/STAT signaling pathway and is regulated by TRIM11. It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells. Humanin is also expressed in colon and testis.
|humanin, l rRNA, MTRNR2, RNR2|
|Antigen Affinity Chromatography|
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|