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STEMCELL Technologies I-BET151

Produktkod. 17160262
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17160262 10 mg
17170262 50 mg
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Produktkod. 17160262 Leverantör STEMCELL Technologies Leverantörsnummer 73712

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Beskrivning

BET family inhibitor; Inhibits BRD2, BRD3, and BRD4

  • I-BET151 is an inhibitor of bromodomain and extra terminal (BET) family proteins
  • BET proteins recognize acetylated lysine residues via their 2 bromodomains (Gallenkamp et al.) I-BET151 inhibits BRD2, BRD3, and BRD4 with IC50 values of 0.5, 0.25, and 0.79 μM, respectively (Kline et al.; Vidler et al.; Hewings et al.; Dawson et al. 2012)
  • Enhances reprogramming of mouse fibroblasts to neurons, in combination with ISX-9, Forskolin, and CHIR99021 (Li et al.)
  • Induces early cell cycle arrest and apoptosis in human and mouse MLL-fusion leukemia cell lines by blocking transcription of key genes including BCL2, C-MYC, and CDK6 (Dawson et al.) 2011)

Specifikationer

CAS 1300031-49-5
Synonym GSK1210151A
Kvantitet 10 mg
Molekylformel C23H21N5O3
Renhet ≥98%
Produkttitel
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