Thermo Scientific™ TheraPure™ iBu-dG Phosphoramidite, 20-400 finish bottle

Description

iBu-dG CEP is a phosphoramidite containing 5' DMT and the nucleoside deoxyguanosine (dG) with isobutyryl (iBu) base protection, for use in oligonucleotide synthesis. DNA phosphoramidites are the building blocks for synthesis of DNA or DNA containing oligonucleotides. Each base has unique protecting groups designed specifically to protect the DNA during the chemical synthesis process, and produce the highest amount of full length product. Alternative protecting groups on dC (acetyl) and dG (DMF) allow for a faster deprotection of the oligonucleotide. The TheraPure trademark denotes a highest level of phosphoramidite purity, developed with the highest stringency of of high definiteion analytics and tightly controlled impurity profiles. Ideal for any therapeutic application. This product is supplied in a 60 mL Amber bottle with a 20-400 Finish neck style, which is compatible with most Expedite Systems of oligonucleotide synthesizers.

Features:
• Full chemical name: 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-deoxyguanosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula: C₄₄H₅₄N₇O₈P
• Base: dG
• Base Protection: iBu
• Formula weight: 839.92 g/mol
• CAS number: 93183-15-4
• HPLC Purity: ≥99%; M-11 Impurity ≤0.01%; Single critical impurity ≤0.3%; Presence of dA, dC, or T impurity ≤0.03%
• ³¹P NMR Purity: ≥99%; Sum of non-primary peaks at 140-152 ppm: ≤0.3%; No peak(s) above 170 ppm; HMT impurity (∼146 ppm): ≤0.10%