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ICAM-1 Monoclonal Antibody (W-CAM-1), Invitrogen™

Product Code. 11344763
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Kvantitet:
500 μL
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500µL
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11344763 500 μL 500µL
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Product Code. 11344763 missing translation for 'mfr' Invitrogen missing translation for 'supplierNo' MA513021

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Description

Mouse Monoclonal Antibody

MA5-13021 targets CD54 in WB, FACS, FN, IF, and IHC (F) applications and shows reactivity with Human samples. The MA5-13021 immunogen is raji Burkitt lymphoma cells.

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ICAM-1
Användningsområden Flow Cytometry, Functional Assay, Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Klassificering Monoclonal
Klona W-CAM-1
Koncentration 0.2 mg/mL
Konjugera Unconjugated
Formulering PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gen ICAM1
Genaccessionsnr. P05362
Gene Alias BB2; CD54; cell surface glycoprotein P3.58; Human rhinovirus receptor; ICAM; Icam1; ICAM-1; ICAM-1; CD54 homolog; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; intercellular adhesion molecule-1; intercellular adhesion molecule-1 precursor; Ly 47; Ly-47; major group rhinovirus receptor; MALA2; MALA-2; MyD10; P3.58; sCD54; soluble CD54; Surface antigen of activated B cells
Gensymboler ICAM1
Värd art Mouse
Immunogen Raji Burkitt lymphoma cells
Reningsmetod Protein A
Kvantitet 500 μL
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 3383
Målarter Human
Innehåll och lagring 4° C
Produkttyp Antibody
Form Liquid
Isotyp IgG2b κ
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