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Invitrogen™ ICAM-3 Monoclonal Antibody (MEM-171), Alexa Fluor™ 488
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Produktkod. 15327414
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Kvantitet:
100 Tests
Förpackningsstorlek:
100 tester
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15327414 100 Tests 100 tester
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Produktkod. 15327414 Leverantör Invitrogen™ Leverantörsnummer MA518145

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Mouse Monoclonal Antibody

This antibody recognizes an extracellular epitope in the D2 domain of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes.

CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.
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Specifikationer

Antigen ICAM-3
Användningsområden Flow Cytometry
Klassificering Monoclonal
Klona MEM-171
Konjugera Alexa Fluor 488
Formulering PBS with 0.2% BSA and 15mM sodium azide
Gen ICAM3
Genaccessionsnr. P32942
Gene Alias CD50; CDw50; ICAM3; ICAM-3; ICAM-R; Intercellular adhesion molecule 3; intercellular adhesion molecule-3
Gensymboler ICAM3
Värd art Mouse
Immunogen Human granulocytes.
Reningsmetod Size-exclusion chromatography
Kvantitet 100 Tests
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 3385
Målarter Human
Innehåll och lagring 4°C, store in dark, DO NOT FREEZE!
Produkttyp Antibody
Form Liquid
Isotyp IgG1
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Produkttitel
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