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IgE Mouse anti-Human, FITC, Clone: Ige21, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-6986-41

Additional Details : Weight : 0.23750kg

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Product Code. 15576576

  • 822.00 SEK / 25 tests

Estimated Shipment: 27-07-2021

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Description

Description

Description: The monoclonal antibody IgE21 recognizes the immunoglobulin E class of antibodies. The natural levels of IgE in the serum are quite low, comprising only a small portion of the total immunoglobulin. IgE plays a role in allergy responses by binding to mast cells and basophils through the Fc epsilon receptor I which results in the release of histamine and other molecules. The IgE is produced by terminally differentiated plasma B cells and basophils. Like all immunoglobulins, IgE is expressed as a soluble molecule as well as a membrane bound form. IgE21 recognizes both forms. Applications Reported: This Ige21 antibody has been reported for use in flow cytometric analysis. Applications Tested: This Ige21 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.

IgE is one of the five classes of immunoglobulins found in mammals. Monomers consist of two heavy (epsilon) chains with 4 Ig-like constant domains, and two light chains. IgE plays an essential role in type I hypersensitivity (allergic responses such as hay fever, asthma, hives, anaphylatic shock) by binding to Fc receptors on basophils and mast cells. Crosslinking of IgE bound to Fc receptors induces degranulation of mast cells and basophils that promote allergic manifestations. IgE is also functionally important for immunity against parasites.
Specifications

Specifications

IgE
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P01854
IGHE
IgG1, kappa
25 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
3497
Flow Cytometry
Ige21
FITC
IGHE
Liquid
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
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