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IKAROS, clone: 2A9-mIkaros, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5780-80

Additional Details : Weight : 0.01000kg

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Product Code. 15277457

  • 1112.00 SEK / 25µg


Estimated Shipment date
from Supplier 26-06-2018
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Description

Description

Description: This 2A9-mIkaros monoclonal antibody reacts with mouse Ikaros, the 70-kDa founding member of the Ikaros family of C2H2-type zinc finger transcription factors. Ikaros is expressed in hematopoietic progenitor cells, thymocytes, mature T and B cells, monocytes, macrophages, and natural killer cells. This protein has also been shown to be expressed in non-immune cells such as neurons. Studies indicate that Ikaros can interact with other family members, namely Aiolos and Eos. Ikaros is involved in thymocyte development, B cell differentiation, cell cycle control, chromatin remodeling, and tumor suppression. Moreover, Ikaros has been implicated in leukemia and lymphoma. Ikaros has been demonstrated to regulate expression of Tdt, CD8a, and Notch target genes.At least eight Ikaros isoforms exist due to alternative splicing. The 2A9-mIkaros antibody has been reported to recognize Ikaros isoform VI (Ik-6), which is the longest and most predominant.Applications Reported: This 2A9-mIkaros antibody has been reported for use in western blotting.Applications Tested: This 2A9-mIkaros antibody has been tested by western blot of reduced mouse splenocytes. This can be used at less than or equal to 5 ug/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Ikaros
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q03267
IKZF1, IKAROS family zinc finger 1 (Ikaros) , Hs.54452, IK1, IKAROS, LYF1, PRO0758, ZNFN1A1, hIk-1 , CLL-associated antigen KW-6, Ikaros (zinc finger protein), zinc finger protein, subfamily 1A, 1 (Ikaros)
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Murine
Western Blot
2A9-mIkaros
Unconjugated
Ikzf1
Purified
Ikzf1
IgG1
25μg
Store at 2-8°C.
Primary
22778
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