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IkB alpha Rabbit anti-Human, Mouse, Porcine, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1656.73 SEK - 4721.67 SEK

Specifications

Antigen IkB alpha
Concentration 0.16 mg/mL
Applications Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16876543
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Proteintech
10268-1-AP-20UL
20 μL
1656.73 SEK
20µL
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Estimated Shipment: 02-04-2024
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16866543
View Documents Promotion Details
Proteintech
10268-1-AP-150UL
150 μL
4721.67 SEK
150µL
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Estimated Shipment: 02-04-2024
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Description

Description

IkB-alpha is a 40 kDa protein that functions to inhibit NF- kappaB activity. The inhibition occurs via protein-protein interaction between I kappaB proteins and NF- kappaB dimers in the cytosol. The interaction of I kappa B-alpha with NF- kappaB masks the nuclear localization sequence of NF- kappaB, preventing NF- kappaB translocation to the nucleus. A variety of stimuli can activate gene expression by liberating NF- kappaB through the degradation of I kappaB alpha. These stimuli include the proinflammatory cytokines TNF- alpha and IL-1 beta, chemokines, PMA, growth factors, LPS, UV irradiation, viral infection, as well as various chemical and physical stresses. In humans, the gene is located on the q arm of chromosome 14. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB. IkB kinase alpha (IKK alpha), previously designated CHUK, interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation Serines 32 and 36. IKK alpha appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKK alpha, IKK beta and IKK gamma, and each appear to make essential contributions to IkB phosphorylation.
Specifications

Specifications

IkB alpha
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Unconjugated
Rabbit
Human, Mouse, Porcine
P25963, Q08353, Q9Z1E3
18035, 406188, 4792
IkB alpha Fusion Protein Ag0345
Primary
-20°C
NFKBIA
0.16 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
I kappa B alpha, IkappaBalpha, IkB alpha, IKBA, MAD 3, MAD3, NF kappa B inhibitor alpha, NFKBI, NFKBIA
Nfkbia
IgG
Antigen Affinity Chromatography
Antibody
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SDS
Documents

Documents

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