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IL-1 alpha Armenian Hamster anti-Mouse, Clone: ALF-161, eBioscience™

Armenian Hamster Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-7011-85

Additional Details : Weight : 0.01000kg

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Product Code. 15247977

  • 2195.00 SEK / 500µg


EU Stock 1
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Description

Description

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 beta. IL1A is located on the q arm on chromosome 2 at position 13. IL-1 alpha plays an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. IL-1 alpha activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. Further, IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and induces apoptosis. The IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL1 alpha regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL-1 alpha can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-1 alpha are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Specifications

Specifications

IL-1 alpha
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P01582
Interleukin-1 alpha, Hematopoietin-1, IL1A
Armenian Hamster
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
ELISA
ALF-161
Unconjugated
Il1a
Liquid
Il1a
IgG
500 μg
4° C
Primary
16175
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