IL-25R (IL-17RB), PE, clone: MUNC33, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 12-7361-80
Additional Details : Weight : 0.09500kg
DescriptionDescription: This MUNC33 monoclonal antibody reacts with mouse interleukin-25 receptor (IL-25R), also known as IL-17RB. IL-25R is a 55kDa transmembrane protein that dimerizes with IL-17RA to form the functional receptor for IL-25 (IL-17E). IL-25R is detectable in various tissues, including the lung and gastrointestinal tract and exists as both membrane bound and soluble form. IL-25/IL-25R interaction has been shown to activate the NF-kB, MAPK, and JNK pathways as well as gene transcription by STAT6, GATA-3, and NFATc1. IL-25R signals in T helper 2 (Th2) cells, type 2 innate lymphoid (ILC2) cells and some iNKT cells to promote differentiation and effector function. Whereas IL-25-deficient mice have an impaired Th2 response to parasitic helminth infection, elevated expression of IL-25 and IL-25R is observed in patients with chronic asthma and atopic dermatitis.Applications Reported: This MUNC33 antibody has been reported for use in flow cytometric analysis.Applications Tested: This MUNC33 antibody has been tested by flow cytometirc analysis of mouse lymph node cells or IL-25R-transfected cells. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2μm post-manufacturing filtered.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|IL-17B, IL-20, MGC138900, MGC138901, ZCYTO7|
|Store at 2-8°C. Do not freeze. Light-sensitive material.|
For Research Use Only.