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IL-38 Monoclonal Antibody (H127C), eFluor™ 660, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
1320.00 SEK - 3355.00 SEK
Specifications
Antigen | IL-38 |
---|---|
Clone | H127C |
Classification | Monoclonal |
Conjugate | eFluor 660 |
Form | Liquid |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15510047
|
Affymetrix eBioscience
50-7385-82 |
100 μg |
3355.00 SEK
100µg |
Estimated Shipment: 18-06-2024 Log in to see stock. |
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15500047
|
Affymetrix eBioscience
50-7385-80 |
25 μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Description: The monoclonal antibody H127C recognizes human IL-38. IL-38 is a member of the Interleukin-1 family (IL-1F) and shares homology with IL-1R antagonist (IL-1Ra) and IL-36R antagonist (IL-36Ra). IL-38 is expressed mostly in the skin and proliferating B cells of the tonsil and is also present at low levels in the heart and placenta. IL-38 functions as an anti-inflammatory cytokine that inhibits IL-36 by binding to IL-36R and also inhibits the production of IL-17 and IL-22. Gene polymorphisms of IL-38 are associated with psoriatic arthritis, ankylosing spondylitis, and heart disease. Applications Reported: This H127C antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections. Applications Tested: This H127C antibody has been tested tested by immunohistochemistry on human FFPE tissue using low pH antigen retrieval and can be used at less than or equal to 5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. eFluor® 660 is a replacement for Alexa Fluor® 647. eFluor® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome. Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.
The cytokine IL-1 is responsible for initiating a variety of activities through the activation of transcription factors, NF-kappa B and AP-1, thereby promoting host response to injury or infection. IL-1F10 (Interleukin-1 family member 10), also known as FIL1T, IL1HY2 or FKSG75, is highly expressed in the skin, spleen and proliferating B-cells of the tonsil. IL-1F10 binds soluble IL-1 receptor type 1, and is one of nine Interleukin 1 families clustered on chromosome 2, where it is thought to participate in the regulation of adapted and innate immune responses. IL-1F10 and IL-1RN polymorphisms may play an important role in the susceptibility to developing rheumatoid arthritis.Specifications
IL-38 | |
Monoclonal | |
Liquid | |
RUO | |
Q8WWZ1 | |
IL1F10 | |
Primary | |
Antibody |
H127C | |
eFluor 660 | |
Mouse | |
Human | |
84639 | |
IgG2b κ | |
Affinity chromatography | |
IL1F10 |
For Research Use Only.