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Invitrogen™ IL-4 Human Uncoated ELISA Kit

Uncoated ELISA Kit

4185.00 SEK - 6010.00 SEK


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Product Code Brand Description Price Quantity & Availability  
Product Code Brand Description Price Quantity & Availability  
15561017
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Invitrogen™
88-7046-77
20 x 96 Tests
6010.00 SEK
Pack of 20
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Estimated Shipment
01-03-2021
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15581017
View Documents
Invitrogen™
88-7046-88
10 x 96 Tests
4185.00 SEK
Pack of 10
View alternative products
Save Up to 
»
Estimated Shipment
01-03-2021
Add to basket
 
Description

Description

The Human Interleukin-4 (IL-4) Uncoated ELISA Kit contains pre-matched antibody pairs, and reagents for performing quantitative enzyme linked immunosorbent assays (ELISA) to detect and quantify protein levels of Human IL-4. Wash Buffer and Stop Solution are needed to complete the ELISA reaction and are sold separately. Principle of the method ELISAs are designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody is coated to the bottom of the wells of a microplate, which is an overnight process. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. A sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.

Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.
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