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Tocris Bioscience™ Indinavir sulfate
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Produktkod. 18738976
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Kvantitet:
50 mg
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Produktkod. Kvantitet
18738976 50 mg
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Produktkod. 18738976 Leverantör Tocris Bioscience™ Leverantörsnummer 7196/50

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Beskrivning

Potent and selective HIV-1 and HIV-2 protease inhibitor

Indinavir sulfate is a potent and selective HIV protease inhibitor (Ki values are 0.52 and 3.3 nM for HIV-1 and HIV-2, respectively). Indinavir stops the spread of the HIV-infected MT4 lymphoid cells at concentrations of 25-50 nM. Indinavir disrupts the ERK1/2 and p38 MAPK pathways and reduces both the level of functional eIF4F complex and rpS6 phosphorylation, which leads to a decrease in protein synthesis in mouse myocytes. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CLpro.
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Specifikationer

Kemiskt namn eller material 2,3,5-Trideoxy-N-[(1 S,2 R)-2,3-dihydro-2-hydroxy-1 H-inden-1-yl]-5-[(2 S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide sulfate
CAS 157810-81-6
Kvantitet 50 mg
Mål HIV Protease Inhibitors
Molekylformel C36H47N5O4.H2SO4
Renhet 0.98
Produkttitel
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