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  6. Invitrogen™ Integrin beta 5 Monoclonal Antibody (KN52), FITC, eBioscience™, Invitrogen™

Invitrogen™ Integrin beta 5 Monoclonal Antibody (KN52), FITC, eBioscience™, Invitrogen™
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Produktkod. 15536416
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Kvantitet:
100 Tests
25 Tests
Förpackningsstorlek:
100 tester
25 tester
Produktkod. Kvantitet unitSize
15536416 100 Tests 100 tester
15526416 25 Tests 25 tester
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Produktkod. 15536416

Brand: Invitrogen™ 11049742

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Beskrivning

Mouse Monoclonal Antibody

Description: The KN52 antibody reacts with human integrin beta 5, an approximately 100,000 Mr (reduced) and 95,000 Mr (nonreduced) a member of the integrin family. Only a single alpha chain, the alpha v subunit, associates with the integrin beta 5 to form the vitronectin receptor complex. Integrin alpha v/beta 5 complex also binds to the basic domain of Tat (he sequence RKKRRQRRR). The integrin beta 5 is found on carcinoma cell lines, hepatoma and fibroblast cell lines, and is absent from lymphoblastoid cells and platelets. The KN52 monoclonal antibody has been shown to inhibit migration. Applications Reported: This KN52 antibody has been reported for use in flow cytometric analysis. Applications Tested: This KN52 antibody has been pre-titrated and tested by flow cytometric analysis of Chinese Hamster Ovary (CHO), A549 and normal human peripheral blood cells. This can be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.

Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around 22 different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell-surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in-groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N-terminal extracellular domain that binds the ECM ligand and a small C-terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen Integrin beta 5
Användningsområden Flow Cytometry
Klassificering Monoclonal
Klona KN52
Koncentration 5 μL/Test
Konjugera FITC
Formulering PBS with BSA and 0.09% sodium azide; pH 7.2
Gen Itgb5
Genaccessionsnr. O70309, P18084
Gene Alias [b]5; [b]-5; [b]5A; [b]5B; AA475909; AI874634; beta5; beta-5; CD61; ESTM23; FLJ26658; GP3A; GPIIIa; I79_000655; integrin beta 5; integrin beta-5; integrin subunit beta 5; integrin, beta 5; ITGB5; RGD1563276; testis secretory sperm-binding protein Li 217p
Gensymboler Itgb5
Värd art Mouse
Reningsmetod Affinity chromatography
Kvantitet 100 Tests
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 100765378, 16419, 3693
Målarter Hamster, Human, Mouse
Innehåll och lagring 4°C, store in dark, DO NOT FREEZE!
Produkttyp Antibody
Form Liquid
Isotyp IgG1 κ
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For Research Use Only.

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