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STEMCELL Technologies IQ-1

Produktkod. 17140122
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Kvantitet:
5 mg
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Produktkod. Kvantitet
17140122 5 mg
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Produktkod. 17140122 Leverantör STEMCELL Technologies Leverantörsnummer 72772

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Beskrivning

WNT pathway activator; Inhibits protein phosphatase PP2A

  • IQ-1 selectively inhibits p300-dependent β-catenin signaling by binding to the PR72/130 subunit of protein phosphatase PP2A, leading to decreased phosphorylation of the β-catenin coactivator, p300, and decreased affinity of p300 for β-catenin
  • IQ-1 thereby inhibits β-catenin/p300 interaction while increasing β-catenin/CBP mediated transcription (Miyabayashi et al.)
  • Used with Wnt3a to maintain pluripotency of mouse embryonic stem (ES) cells in the absence of mouse embryonic fibroblasts (MEFs), serum, or exogenous leukemia inhibitory factor (LIF; Miyabayashi et al.)
  • Enhances expansion of mouse ES-derived cardiovascular progenitor cells (Schenke-Layland et al.)
  • Induces the conversion of cancer cells to a side population of cancer stem-like cells with high levels of drug resistance and tumorigenicity (He et al.)

Specifikationer

CAS 331001-62-8
Kvantitet 5 mg
Molekylformel C21H22N4O2
Renhet ≥98%
Produkttitel
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