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Tocris Bioscience™ Ivosidenib

Produktkod. 18798656
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Produktkod. Kvantitet
18798656 50 mg
18736926 10 mg
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Produktkod. 18798656 Leverantör Tocris Bioscience™ Leverantörsnummer 7761/50

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Beskrivning

Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

Ivosidenib is a potent inhibitor of mutant isocitrate dehydrogenase enzyme 1 (mIDH1), with activity against a variety of mutant IDH1 enzymes (IC50 range = 5-19 nM). Reduces intracellular 2-HG (Cat. No. 6122) by 96% at 0.5 μM. Increases sensitivity of melanoma to Temozolomide (Cat. No. 2706) in vivo and inhibits wild-type IDH1 in low magnesium and low nutrient levels. Ivosidenib also inhibits growth of tumors in cell and animal models of pancreatic cancer and inhibits invasion and migration of chondrosarcoma cells in vitro.
TRUSTED_SUSTAINABILITY

Specifikationer

Kemiskt namn eller material (2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
CAS 1448347-49-6
Kvantitet 50 mg
Mål Isocitrate Dehydrogenase 1/IDH1
Molekylformel C28H22ClF3N6O3
Produkttitel
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