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JAK2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 17670-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16877604

  • 1236.20 SEK / 20µL
Estimated Shipment: 08-12-2021

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Description

Description

Janus Activating Kinase 2 (JAK2) is a non-rececptor tyrosine kinase involved in various processes such as cell growth, development, differentiation, and histone modifications. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting this gene can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
Specifications

Specifications

JAK2
0.34 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O60674, Q62120, Q62689
JAK 2, JAK2, Janus kinase 2, JTK10, Tyrosine protein kinase JAK2
Rabbit
IgG
20 μL
-20°C
Primary
16452, 24514, 3717
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
JAK2
Liquid
Jak2
JAK2 Fusion Protein Ag11264
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Rat, Human, Mouse
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