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JAK2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1236.20 SEK - 3313.85 SEK

Specifications

Antigen JAK2
Concentration 0.34 mg/mL
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate Unconjugated
Format Liquid
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16867604
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Proteintech
17670-1-AP-150UL
150 μL
3313.85 SEK
150µL
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Estimated Shipment: 20-01-2022
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16877604
View Documents Promotion Details
Proteintech
17670-1-AP-20UL
20 μL
1236.20 SEK
20µL
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Estimated Shipment: 20-01-2022
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Description

Description

Janus Activating Kinase 2 (JAK2) is a non-rececptor tyrosine kinase involved in various processes such as cell growth, development, differentiation, and histone modifications. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting this gene can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
Specifications

Specifications

JAK2
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Polyclonal
-20°C
0.34 mg/mL
Unconjugated
Rabbit
Rat, Human, Mouse
IgG
Antigen Affinity Chromatography
Antibody
SDS
Product Certifications